Background: Comedone formation has an essential role in pathophysiology of ACNE, therefore destroying of comedones and preventing of comedone formation is very important in ACNE treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of ACNE. Patients & Methods: In this open clinical trial without control group, 30 patients with ACNE referred to Razi Hospital in Tehran (mean age 18) years were treated with 70% glycolic acid and their clinical improvement was evaluated. Results: Mean numbers of comedones were 24.4± 15.2 and 2.6±5.9 in first & last visits respectively (P<0.005). Moreover, 18 patients (60%) and 12 patients (40%) had complete and relative improvement, respectively. The side effects of this treatment were minimum and transient. Conclusion: Superficial peeling with 70% glycolic acid is effective in treatment of MILD ACNE.      

Background: ACNE vulgaris is the most common cause for dermatology visits and is one of the most common diseases that people experience during their lives. Although this disease is not life-threatening, it may affect the life quality of the patients because of developing irreparable complications on the skin. Dermatologists are in agreement about topical treatment in the MILD to moderate ACNE vulgaris, but extensive using of tropical antibiotics and drug resistance have decreased their therapeutic benefits. In this study, we tried to compare the therapeutic effects of tropical azithromycin and clindamycin.Methods: This study was designed and performed as a double blind, randomized clinical trial. Thirty two patients with MILD to moderate ACNE were treated with azithromycin and 30 patients, who were matched with the former group based on age, sex and severity of the disease, were treated with clindamycin for 12 weeks and results of their treatment were compared with each other.Results: results of this study showed that ratio of response to treatment and decreasing the grade of the disease and number of nodules, papules and pustules were not significantly different in the first month of the treatment in both groups while just the number of nodules in the group on azithromycin showed more decrease in the last months of treatment in comparison with clindamycin (0.88±0.75 vs. 0.25±0.75, p=0.015). Also, clindamycin had more side effects, but the rate of satisfaction with both drugs were high and showed no difference. In this study, no significant association was found between sex and response to treatment and evaluation of association between age and response to treatment showed a significant reverse association between age and decreasing the number of pustules (p=0.002 , r= - 0.492).Conclusion: sum of findings in this study show that topical azithromycin is an effective antibiotic with acceptable side effects and high degree of satisfaction in patients and it can be used for the treatment of MILD forms of ACNE.

ACNE agminata is a rare dermatosis of unknown etiology. Occurs predominantly in young adults. The disease is in the form of eruptions of brown, monomorph, multiple and symmetrical papules occuring in the chin, forehead, face and eyelids. Diascopy often shows apple-jelly appearance. Lesions, histologically have a granulomatous appearance with a central caseification. The lesions heal with scars. The patient was a 30 year old man admitted to Boo Ali Sina hospital with brown papules of yellow tip scattered on chin, eyelids and face. Histological study showed granulomatous lesion with caseificated center located in the dermis. Considering the clinical and histological findings, patient was diagnosed as a case of ACNE agminata and was treated with dapson for 8 months. The lesions regressed completely with little remained pitted scars. The recurrence was not seen in follow up. In case of observation of the patients with above mentioned clinical manifestation, biopsy of lesions is necessary. In order to prevent scar formation, the treatment must be started as soon as the diagnosis is confirmed.

Background: ACNE vulgaris is a very common disorder affecting virtually every adolescent at some point in time. Topical treatment of ACNE involves the use of retinoids and antimicrobials. Antimicrobials reduce P. ACNE population and are effective for treatment of inflammatory lesions. We evaluated the efficacy and safety of topical ciprofloxacin solution and compared it with topical erythromycin solution.Methods: The study was a prospective single-blind clinical trial. One hundred patients with MILD to moderate ACNE were enrolled. The patients were randomly treated with topical application of 0.3% ciprofloxacin or 4% erythromycin solutions. For a six week period, they were visited every two weeks. ACNE severity index (ASI) was calculated in each visit and recorded.Results: Ninety-three patients completed the study, 50 patients in the ciprofloxacin and 43 in the erythromycin groups. Irritation was generally MILD for both treatments and no discontinuation was reported because of adverse effects. There was no statistically significant difference between the two treatment groups in reduction of comedons or papules but reduction of pustules was greater in ciprofloxacin treatment group after 4 weeks. ASI was reduced in the two groups but in ciprofloxacin treated patients, this reduction was more significant at all follow up visits.Conclusion: The results of this study indicate that topical solutions of erythromycin and ciprofloxacin were effective in treating MILD to moderate ACNE vulgaris and both were well-tolerated by the patients. Ciprofloxacin solution produced greater reduction in pustule counts and ASI, during the six week period of twice-daily application. This novel modality may have an important potential role in rotational topical therapy of inflammatory ACNE lesions.

Background and Objective: Considering the role of bacteria in causing some forms of ACNE, in recent years, the use of antibiotics along with other medications has had positive results in ACNE treatment,therefore, the present study aimed to compare the effect of the combination of topical erythromycin and zinc acetate with topical erythromycin alone in treating MILD to moderate ACNE vulgaris. Materials and Methods: In this clinical trial, 76 patients with ACNE vulgaris who were referred to a specialized skin clinic were selected and randomly assigned into two treatment groups, namely, A (n=39) and B (n=37). Group A was treated with a local solution of erythromycin 4% without zinc acetate, and group B was treated with a combined local solution of erythromycin 4% and zinc acetate 1. 2%. The treatment continued twice a day for three months. Results: In groups, A and B, respectively, the average lesion intensity score before treatment was 21. 1 ±,6. 5 and 21. 9 ±,5. 4 (P=0. 555), the first month of treatment was 17. 0 ±,6. 4 and 15. 7 ±,5. 9 (P=0. 578), the second month of treatment 9. 1 ±,4. 5 and 6. 4 ±,3. 3 (P=0. 014), the third month of treatment 4. 0 ±,3. 0 and 2. 0 ±,3. 0 (P=0. 001), and the frequency of complete recovery was 38. 5 and 64. 9%, respectively (P=0. 021). In group B, the severity of papules in the second (P=0. 002) and third (P=0. 001) months of the treatment was significantly lower than in group A. Conclusion: Based on the obtained results, using a combination of erythromycin 4% with zinc acetate 1. 2% as a topical solution is more effective than the topical solution of erythromycin 4% alone in treating ACNE lesions.

Introduction: Topical antimicrobials, such as clindamycin, are effective in the treatment of ACNE and azelaic acid, due to the lack of bacterial resistance, could be a useful alternative in topical treatment of ACNE. The aim of this study was to compare the effect of topical azelaic acid 20% with clindamycin 1% lotion for the treatment of ACNE.Method: This randomized clinical trial study was performed on 108 patients with MILD and moderate ACNE. Patient were randomly assigned to one of the two groups of treatment with azelaic acid 20% cream (50 patients) or clindamycin 1% lotion (58 patients). The patients were evaluated by grading and lesion counting methods before treatment and one month and two months after the treatment.Results: The mean age of the patients in clindamycin group and azalic acid was 19.6±3.9 and 20.3±4.5 years, respectively (P=0.41). The mean score of ACNE severity decreased after treatment according to grading and lesion counting methods (P<0.05). Reduction of ACNE severity score between two group was not significant in second and third visit compared to before treatment (P>0.05)Conclusion: Result showed that the azelaic acid 20% topical cream was as effective as clindamycin 1% lotion for treating MILD to moderate ACNE.

Background: ACNE is the most common chronic skin disease affecting young adults and adolescents worldwide. A characteristic of this disease is the chronic inflammation of sebaceous glands leading to comedones, papules, pustules, nodules, and cysts. Topical and systemic uses of medicines are common approaches to treat ACNE. However, these medicines are associated with some adverse effects and increased microbial resistance. Objectives: We aimed to prepare and apply an herbal formulation containing several herbs with different effects on mechanisms associated with ACNE formation. Methods: In this study, 66 patients with MILD-to-moderate ACNE randomly received a packet containing herbal medicine or clindamycin gel. The treatment period was two months, and the total ACNE lesions and ACNE severity index were measured every four weeks. After eight weeks of treatment and follow-up, the physician examined clinical outcomes and possible complications. Results: Decreases in total ACNE lesions and ACNE severity index were significantly different in both treatment groups (P < 0. 05 in both groups). Although the herbal cream provided better improvement than clindamycin, there was no significant difference between the two groups (P > 0. 05). Conclusions: The use of the herbalcreamcould berecommendedfor treating ACNE lesionsdueto few complications, greater patient satisfaction, and avoiding microbial resistance to chemical antimicrobials.